Interaction of actinomycin D, radiation and yeast cell survival
نویسندگان
چکیده
منابع مشابه
Joint lethal effects of actinomycin D and radiation in mice.
These studies are primarily concerned with recovery from sublethal actinomycin D or radiation damage as measured by joint lethality of the two treatments separated by an interval of 1 hr to 4 days. In mice given actinomycin D and challenged with radiation, the high mortality attributable to joint treatment decreased steadily between the 6-hr and the 3-day challenge. On the other hand, in mice g...
متن کاملModification of the radiation response determined by single-cell technics: actinomycin D.
Modification of the response of mammalian cells to ionizing radiation has long interested clinicians and other investigators (1, 2). Technics for study of radiation effects on single cells (17, 18) offer opportunities to obtain quantitative information about effects of drugs, radiation, and other agents, alone or in combination (3, 15). Most information in this report concerns actinomycin D, an...
متن کاملResponse of yeast and mycelial phases of Histoplasma capsulatum to amphotericin B and actinomycin D.
The dimorphic fungus Histoplasma capsulatum exists in two phases: a unicellular yeast form at 37 C and a mycelium at 25 C. We have found that these two phases have selective drug susceptibilities. The mycelial form of H. capsulatum was much more susceptible to the polyene antibiotic amphotericin B than the yeast form; in contrast, the yeast form was more susceptible to the antibiotic actinomyci...
متن کاملEffects of actinomycin D and ultraviolet and ionizing radiation on Pichinde virus.
Actinomycin D (0.05 mug/ml) suppresses the synthesis of ribosomal RNA of baby hamster kidney (BHK21) cells. The production of infectious Pichinde virus was enhanced in the presence of actinomycin D, although the production of virus particles was not substantially different from cultures inoculated in the absence of the drug. By prelabeling BHK21 cells with (3)H-uridine and then allowing the vir...
متن کاملSuppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D.
For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1975
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1975.304